Abstract:
This dissertation aimed to investigate and evaluate the possible
phytochemical and biological profiles like, phytochemical screening,
antioxidant, antimicrobial, cytotoxic and hypoglycemic activities of the
medicinal plant Albizia richardiana (Fam. Fabaceae, subfam.
Mimosoideae). Phytochemical screening test of the methanolic plant
extract of Albizia richardiana suggests the presence of bioactive
substances like- carbohydrates, saponin, glycosides, glucosides,
alkaloids in the bark extract of plant. Antioxidant activity was screened
using DPPH assay and ethyl acetate soluble partitionate of bark
revealed the significant free radical scavenging activity with IC50
values of 17.8 μg/ml as compared to standard, butylated hydroxyl
toluene (IC50 11.62 μg/ml). In the brine shrimp lethality bioassay, the
chloroform soluble extractive from bark showed cytotoxicity (LC50 = 22.03 µg/ml) as compared to vincristine sulfate (LC50 = 0.52 µg/ml). Significant hypoglycemic activity was observed after 60 and 120 minutes of administration. No significant antimicrobial was observed from this plant part. Chemical investigation of the bark extract of Albizia richardiana, for the first time from this plant. This is the also the first report of the bioactivities of this plant.
