Abstract:
This dissertation aimed to compare the antihyperlipidemic effects of
methanolic extract of Zingiber officinale, Momordica charantia,
Trigonella foenum-graecum, Dillenia indica and Tamarindus indica in
hyperlipidemic animal models. Atorvastatin was used as standard drug.
The crude extract (100 mg/kg) of these significantly prevented the
increase in low density lipoprotein (LDL), total cholesterol (TC),
triglyceride (TG) and significantly increased the HDL level in blood
serum. The reduction in serum level of above parameters was
compared with atorvastatin and then within themselves. Among the
five samples, Zingiber officinale extract showed significant Cholesterol
reduction property (p<0.001) compared to other extracts. Momordica
charantia & Dilenia indica (p<0.001) significantly increased the blood HDL cholesterol level. Zingiber officinale, Dilenia indica & Tamarindus indica significantly reduced LDL level in blood (p<0.001). Momordica charantia & Trigonella foenum-graecum significantly reduced TG level (p<0.001) in blood serum of rats. So, the above results confirmed that all extracts are potent against hyperlipidemia
