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Cryptolepine, isolated from sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis
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| dc.contributor.author | Ahmed, Firoj | |
| dc.contributor.author | Toume, Kazufumi | |
| dc.contributor.author | Ohtsuki, Takashi | |
| dc.contributor.author | Rahman, Mahmudur | |
| dc.contributor.author | Sadhu, Samir Kumar | |
| dc.contributor.author | Ishibashi, Masami | |
| dc.date.accessioned | 2014-08-19T23:20:56Z | |
| dc.date.available | 2014-08-19T23:20:56Z | |
| dc.date.issued | 2010 | |
| dc.identifier.citation | Wiley Online Library, 2010 | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/258 | |
| dc.description.abstract | Bioassay guided separation of sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2–3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Wiley Online Library | en_US |
| dc.subject | Sida acuta | en_US |
| dc.subject | Malvaceae | en_US |
| dc.subject | Cryptolepine | en_US |
| dc.subject | TRAIL-induced apoptosis | en_US |
| dc.subject | AGS cell lines | en_US |
| dc.title | Cryptolepine, isolated from sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis | en_US |
| dc.type | Article | en_US |
