Abstract:
Cleome viscosa Linn. (Family: Capparaceae) is an annual and sticky herb and comm
only known as wild or
dog mustard. It has various ethnomedicinal values as various traditional communities find diverse medicinal
properties. This study aimed to investigate the antioxidant, analgesic, anti
-
inflammatory and CNS depressant
activities of cru
de methanolic extract, chloroform fraction as well as ethyl acetate fraction of Cleome viscosa
Linn. In DPPH free radical scavenging activity, in total antioxidant activity and in reducing power capacity
tests the chloroform fraction showed stronger activi
ty than that of the crude methanolic extract and its ethyl
acetate fraction with an IC50 value 4.1 which is almost equal to that of the standard ascorbic acid (3.8),
absorbance of 1.139 and 1.495 respectively. But total phenolic content and total flavonoid
content were
found to be significantly higher in ethyl acetate fraction (264.11±16.2595 and 224.79±7.1686) than that of
the crude methanolic extract and its chloroform fraction. In analgesic activity study using acetic acid induced
writhing test chlorofor
m fraction showed highest activity (writhing inhibition 81.25%, 50 mg/kg b.w). In
anti
-
inflammatory activity study following carrageenan induced paw edema test ethyl acetate fraction
showed potent anti
-
inflammatory activity, on the other hand crude methano
lic extract and chloroform
fraction showed moderate activity. In CNS depressant activity using hole cross and open field test it was
observed that all the extract showed moderate activity in hole cross method while in open field method the
crude methanolic
extract showed the highest activity
